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Biomaterials 33 , — Cakmak, I. Synthesis and characterization of novel antimicrobial cationic polyelectrolytes. Pascual, A. Broad-spectrum antimicrobial polycarbonate hydrogels with fast degradability. Biomacromolecules 16 , — Chiefari, J. Living free-radical polymerization by reversible addition-fragmentation chain transfer: the RAFT process. Macromolecules 31 , — Atom transfer radical polymerization in the presence of transition-metal complexes.

Gelman, M. Biocidal activity of polystyrenes that are cationic by virtue of protonation. Krishnan, S. Surfaces of fluorinated pyridinium block copolymers with enhanced antibacterial activity. Langmuir 22 , — Park, E. Antibacterial activities of polystyrene-block-poly 4-vinyl pyridine and poly styrene-randomvinyl pyridine. Oda, Y. Block versus random amphiphilic copolymers as antibacterial agents. Biomacromolecules 12 , — Chen, C.


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  • To Leach or not to Leach – Antimicrobial Polymer Materials;

Quaternary ammonium functionalized poly propylene imine dendrimers as effective antimicrobials: Structure-activity studies. Biomacromolecules 1 , — Ortega, P. Hyperbranched polymers versus dendrimers containing a carbosilane framework and terminal ammonium groups as antimicrobial agents. Takahashi, H. Molecular design, structures, and activity of antimicrobial peptide-mimetic polymers. Horne, W. Foldamers with heterogeneous backbones. Hancock, R. Antimicrobial and host-defense peptides as new anti-infective therapeutic strategies. Peschel, A. The co-evolution of host cationic antimicrobial peptides and microbial resistance.

Fjell, C. Designing antimicrobial peptides: form follows function. Melo, M. Antimicrobial peptides: linking partition, activity and high membrane-bound concentrations. Brogden, K. Antimicrobial peptides: pore formers or metabolic inhibitors in bacteria? Hall, K. Chen, H. Design of antibacterial peptide-like conjugated molecule with broad spectrum antimicrobial ability. China Chem. Oren, Z. Peptide Science 47 , — Chongsiriwatana, N. Peptoids that mimic the structure, function, and mechanism of helical antimicrobial peptides. USA , — Epand, R. Biochemistry 43 , — Liu, D. Hamuro, Y. Porter, E.

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Antimicrobial polymer - Wikipedia

Amphiphilic polymethacrylate derivatives as antimicrobial agents. Mowery, B. Mimicry of antimicrobial host-defense peptides by random copolymers. Cationic spacer arm design strategy for control of antimicrobial activity and conformation of amphiphilic methacrylate random copolymers.

Biomacromolecules 13 , — Song, A. Antibacterial studies of cationic polymers with alternating, random, and uniform backbones. ACS Chem. Lienkamp, K. Antimicrobial polymers prepared by ROMP with unprecedented selectivity: a molecular construction kit approach. Antimicrobial polymers as synthetic mimics of host-defense peptides.

Biomedical applications of polymers

Wiley Interdiscip. Synthetic mimics of antimicrobial peptides—a versatile ring-opening metathesis polymerization based platform for the synthesis of selective antibacterial and cell-penetrating polymers. Liu, R. Nylon-3 polymers active against drug-resistant Candida albicans biofilms. Nylon-3 polymers with selective antifungal activity. Synthetic polymers active against Clostridium difficile vegetative cell growth and spore outgrowth.

Ternary nylon-3 copolymers as host-defense peptide mimics: beyond hydrophobic and cationic subunits.

Antimicrobial polymer

Tuning the biological activity profile of antibacterial polymers via subunit substitution pattern. Structure—activity relationships among antifungal nylon-3 polymers: identification of materials active against drug-resistant strains of Candida albicans. Nylon-3 polymers that enable selective culture of endothelial cells. Qian, Y. The design, synthesis and biological activity study of nylon-3 polymers as mimics of host defense peptides. Acta Polym. Barrow, S. Cucurbituril-based molecular recognition. Kim, J.


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  • Recent Advances in Antimicrobial Polymers: A Mini-Review.
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Wei, T. Multifunctional and regenerable antibacterial surfaces fabricated by a universal strategy. ACS Appl. Interfaces 8 , — A supramolecular antibiotic switch for antibacterial regulation. Supramolecular conjugated polymer systems with controlled antibacterial activity. Langmuir 33 , — Huang, Z.

Polypseudorotaxane constructed from cationic polymer with cucurbit[7]uril for controlled antibacterial activity. Shima, S. Li, S. An eco-friendly in situ activatable antibiotic via cucurbit[8]uril-mediated supramolecular crosslinking of branched polyethylenimine.

Supramolecular conjugated polymer materials for in situ pathogen detection. Klibanov, A. Permanently microbicidal materials coatings. Hetrick, E. Reducing implant-related infections: active release strategies. Ferreira, L. Non-leaching surfaces capable of killing microorganisms on contact. Hall-Stoodley, L. Bacterial biofilms: from the natural environment to infectious diseases. Pavithra, D. Biofilm formation, bacterial adhesion and host response on polymeric implants-issues and prevention.

1. Introduction

Harding, J. Combating medical device fouling. Trends Biotechnol. Cao, Z. Manipulating sticky and non-sticky properties in a single material. A polycationic antimicrobial and biocompatible hydrogel with microbe membrane suctioning ability. Download references. Correspondence to Xi Zhang. To obtain permission to re-use content from this article visit RightsLink.

Polymer Journal Chinese Journal of Polymer Science Science China Chemistry Article metrics. Activity has been observed against various bacteria and fungi including S. We have also seen that this activity is maintained against resistant strains such as against vancomycin and methicillin dual-resistant S. This technology is also not toxic towards human cells with haemocompatibility studies using human red blood cells and cytotoxicity assays using mammalian cells showing that polymers display minimal toxicity within therapeutic concentrations.

With 'host defence peptides' protecting their hosts from the threat of invading bacteria for millions of years now, and bacteria still showing little sign of developing resistance to them, it makes perfect sense that we should look back to Mother Nature and learn our lessons from her on this one. Artificial polymer-infused materials in the form of wound dressings and catheter coatings may be the answer to treating infections that are currently threatened by antibiotic resistant bacteria.

Potential applications include:. The team is seeking partners to take this technology forward to the clinic. Do business with Manufacturing. We partner with small and large companies, government and industry in Australia and around the world. Biotech and chemicals RAFT.

Recent Advances in Antimicrobial Polymers: A Mini-Review

The challenge Increased antimicrobial resistance is challenging global public health Enlarge image. Our response Mimicking nature - finding new ways of administering infection-fighting drugs Our RAFT team has been developing ways to mimic the protective peptides using polymers — a synthetic material that is not so easily broken down. Enlarge image. The results Optimal candidates identified Enlarge image.

Identification of optimal candidates. Do business with us to help your organisation thrive We partner with small and large companies, government and industry in Australia and around the world. Contact us now to start doing business. Contact us. What is the nature of your enquiry? Oops, something went wrong!