The dock's ladder rots and gives way, causing Paul to fall into the infected water, ensuring that he is definitely infected by this point.
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Back at the cabin, Marcy is shown shaving her legs in the bathtub and notices they are beginning to deteriorate as the skin begins gorily peeling off. She runs outside, upset, and is attacked by a now infected Dr. Paul returns to find Marcy's body ripped to pieces and Dr. Mambo eating a motionless Karen's face. The dog attempts to attack him too. However, Paul kills him with Bert's rifle. Now alone, Paul goes to check on Karen whose skin has now almost fully rotted off; she is barely alive.
To end her suffering, he clubs and impales her with a shovel and then runs for help. Just then, Bert struggles back to the cabin with the rednecks in pursuit. When Bert's pursuers open the door, Bert tries to shoot one of the men but is killed by a shotgun round. Paul comes and successfully kills the store owner and his friends. After fleeing the cabin, Paul decides to look for Jeff.
He checks a cave, thinking Jeff is inside, but only finds Grimm's dead body. Paul then runs back to Bert's pursuers' car and drives into town. Along the way he slams head-on into a deer, damaging the windshield and the car. He continues on foot until he sees a roadside party thrown by local teens with Winston in attendance. Winston asks Paul about the tow truck just as a police officer gets on the radio warning Winston about Paul and his group whom are infected with a strange disease and that they are to be shot on sight. After all of the party attendees leave, Paul knocks Winston out with a stick.
Paul is picked-up by a passing trucker and brought to the hospital.
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The sheriff and doctors interrogate him while he is lying in a hospital bed, trying to discover the source of the infection, but Paul is slightly dazed and unable to answer all their questions. When he is left alone, Paul pulls up his hospital gown to reveal the tell-tale marks of the disease on his belly. The doctors determine they are not equipped to handle the situation and that he should be transported to a larger, nearby regional hospital.
His driver turns out to be Winston. Paul tries to warn him about the water in the reservoir but he can't speak well and only says "water". Winston says he will take him to get water. The next morning, Jeff comes out of the woods where he was hiding and makes his way back to the cabin. As he looks around, horrified that his friends are dead, he is suddenly shot to death by the redneck police. The murderous sheriff and his men take Jeff's dead body and pile it on top of the others, which are burned in a fire pit. While unconscious, Paul is dumped into a stream by Winston and left to die.
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Paul's body infects the water in the stream. Further down are two kids collecting water for their lemonade stand. They sell some lemonade to the sheriff, his deputies and more locals at the store. A natural spring water truck leaves the store with bottles of infected water in the truck Eli Roth originally got the idea for this movie while working in Iceland on a horse farm.
He got such a bad skin infection from the rotting hay in the barn that his face broke out in sores, bled and peeled off when he shaved. Early attempts to sell the script were unsuccessful because studios felt that the horror genre had become unprofitable. In , the film Scream was released to great success, leading studios to once again become interested in horror properties.
However, Roth still could not sell his script, as studios told him that it should be more like Scream. Many potential financiers also found the film's content to be unsettling, including not only the gore, but the use of the word "nigger" early in the film. The rest of the money was raised during the shooting.
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The original killer dog was so old and tired that all of its scenes had to be re-shot with a new dog. With no time or money to find a replacement, the producers cast a real police attack dog that was so vicious and unpredictable that no actors could appear with it on camera. Composer Angelo Badalamenti agreed to compose some musical themes for the film out of enthusiasm for the material. However, the bulk of the film's score was composed by Nathan Barr who has gone on to score both of Eli's Hostel films.
Actor Michael Rosenbaum was originally cast to play Justin aka Grim, but when Rosenbaum wasn't able to commit to the shoot due to another production, Smallville , that was taking off, the role was filled by the director himself. Joey Kern sustained numerous unrelated injuries to his eye during filming, each one requiring a trip to hospital. His injuries disrupted the filming schedule and many scenes that were to be shot later were rescheduled at the last minute, so that minimal shooting time would be lost while Kern recovered.
She says if she can get off work that night, she will meet him there.
John asks Cassie to go to prom but she refuses. Meanwhile, Winston is at a restaurant where a worker from the bottled-water company dies from the infection.
He then realizes the creek got heavily contaminated and goes to the water plant to tell the officials that the water is contaminated. Winston leaves before they can get to him. At the high school the infection begins to spread slowly.
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Principal Sinclair Michael Bowen then kicks John out. Cassie follows him and John angrily confesses his love to her. The CCD locks all of the main exits from the school and kill Principal Sinclair when he demands to know what is going on. The infection then begins to kill the students in the gym at an alarming rate. The gym is then gassed from the outside. Cassie, John, and Alex watch in horror as all the students are killed.
Winston is picked up by his cousin Herman Mark Borchardt , ready to leave town. Alex discovers he is infected and that the disease is incurable necrotizing fasciitis. The only way to stop the infection is to amputate the infected limb. However, Alex's infection is already too severe and he stays behind. John begins to show signs of the infection too and lets Cassie amputate his hand to stop it. Cassie's boyfriend Marc then comes out of nowhere, hits Cassie with a hammer , and tries to kill John but Cassie recovers and kills him with a nail gun.
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